Antiviral activity of flavonoids with a DNA virus [herpes simplex type 1] and RNA virus [vesicular stomatitis virus]

Cytotoxicity and antiviral activities of 38 flavones and flavonols were determined. Several general trends were observed, but the lack of consistent structure-activity relationship suggested the need to conduct additional studies under conditions which measure antiviral activity by a single mechanism or at a discrete point in the virus replication cycle. Consistent with this, seven flavonoids that exhibited substantial cytotoxicity and /or antiviral activity were examined for direct viricidal action on isolated virions prior to infection

Inhibition of oncogene activity as a strategy for identifying cancer chemopreventive agents: Novel inhibitors of protein-tryosine kinase

Twenty-seven naturally occurring phenolic compounds of diverse chemical structures were tested for their ability to inhibit epidermal growth factor receptor kinase isolated from A431 cells. Two compounds; namely, purpurogallin and gliotoxin, were highly active exhibiting 98.6 and 97.3% inhibition at 100 ug/mL, respectively. At a lower testing concentration [10 ug/mL], both compounds exhibited almost 80% inhibition

Larvicidal potency of some extracts from wild Egyptian plants to Culex pipiens

Out of fifty Egyptian plant extracts tested against the 4th larval instar of Culex pipiens, seven extracts possessed insecticidal activity. Extracts of Lyciums shawii was the most toxic [LC50, 45.76 mg/l]. Other active extracts were these of Ononis vaginalis [58.2 mg/l], Ranunculus sceleratus [91.11 mg/l], Ammi majus [109.5 mg/l], Salvia lanigera and Moricandia nitens [126.9 mg/l], and Alkanna tinctoria [138.5 mg/l]. The rest of the plant extracts were less or non-active at 100 mg/l